The glycopeptide antibiotic vancomycin has bactericidal activity against aerobic and anaerobic Gram-positive bacteria including multi-resistant staphylococci. However, there are reports of Staphylococcus aureus with reduced susceptibility to glycopeptides. There are increasing reports of glycopeptide-resistant enterococci. Penetration into cerebrospinal fluid is poor.
Clostridioides difficile infection
By mouth
- For Adult
125 mg every 6 hours for 10 days; increased if necessary to 500 mg every 6 hours for 10 days, increased dose if life-threatening or refractory infection.
Moderate diabetic foot infection,
Severe diabetic foot infection,
Leg ulcer infection
By intravenous infusion
- For Adult
15–20 mg/kg every 8–12 hours (max. per dose 2 g) adjusted according to plasma-concentration monitoring.
Cellulitis,
Erysipelas
By intravenous infusion
- For Adult
15–20 mg/kg every 8–12 hours (max. per dose 2 g) adjusted according to plasma-concentration monitoring.
